| 세션명 | 의료용 고분자 부문위원회 (II) |
|---|---|
| 발표장 | 제2회장 |
| 논문코드 | 2L2-1 |
| 발표일 | 2021-10-22 |
| 발표시간 | 10:30-10:55 |
| 논문제목 | Polysaccharide-based Nano-PAMP Technology for Cancer Immunotherapy |
| 발표자 | Sejin Son |
| 발표자 소속 | University of Michigan |
| 저자 | Sejin Son† |
| 소속 | University of Michigan |
| 논문초록 | Microbial pathogens present “danger” signals at the site of infection and confers protective immunity by inducing proinflammatory cytokines and mobilizing leukocytes. During microbial infection, pathogen associated molecular patterns (PAMPs) activate pattern recognition receptors (PRRs) expressed on innate immune cells, such as dendritic cells (DCs), leading to the production of proinflammatory cytokines, including IL-1β, IL-6, and IL-23, that promote the differentiation and stabilization of T helper 17 (Th17) cells. We have recently reported the development of Saccharomyces cerevisiae (S. cerevisiae) mannan-based nanocapsules (Mann-NC) for subcutaneous delivery of mRNA-based vaccines against cancer. We also demonstrate here that Mann-NC composed of mostly mannan (without any other cargo) is a potent nano-PAMP for Dectin-2 and TLR-4 activation and that intratumoral administration of Mann-NC generates robust Th17 responses in favor of antitumor effects. PAMP-PRR interaction is controlled by the geometry, nanoscale arrangement, and architecture of PAMP on Mann-NC for multivalent surface PAMP arrangement with structural flexibility for favorable PRR engagement. |
THE POLYMER SOCIETY OF KOREA